Many medications can help treat depression. If you're curious about your options, check out this list of antidepressants.. These medications are safer and generally cause fewer bothersome side effects than other types ofantidepressants. SSRIs include fluoxetine (Prozac, Selfemra), paroxetine (Paxil, Pexeva), sertraline (Zoloft), citalopram (Celexa) and escitalopram (Lexapro). Serotonin and norepinephrine reuptake inhibitors (SNRIs).